What is mass spectrometry?

with inductively coupled plasma (ICP-MS)

Secure a clear and simple system for data acquisition and management for your laboratory and all subsequent work processes. But the Fink & Partner LIMS should not be just a central storage module for you. Your measurement data and results are processed with us as your partner in a multi-layered system with individual application possibilities and are available for archiving, visualization or further processing.

Especially in laboratories in which several analyses and examinations are carried out simultaneously, clarity and structure are two of the most important working foreign exchange rates that must be observed.

Mass spectrometry with inductively coupled plasma – ICP-MS

Inductively coupled plasma mass spectrometry (ICP-MS) is a very special method of analysis. This method is very robust and at the same time extremely sensitive and widely used in inorganic elemental analysis. There it is mainly used for trace analysis of heavy metals such as lead, cadmium or mercury.

Procedure of mass spectrometry with inductively coupled plasma (ICP-MS)

In the course of the ICP-MS an atomization process of the analyte takes place first. Ionized argon is induced by a very high-frequency current and the sample of the analyte is heated to 5,000 up to 10,000 °C. The sample is then atomized and the analyte is then heated to 5,000 up to 10,000 °C. The sample is then heated to a temperature of 10,000 °C. The sample is then heated to a temperature of 5,000 °C. This ionizes the atoms and creates a plasma. The ions generated in this plasma are now accelerated in the direction of the analyzer by an electric field. At this point, the individual elements and their isotopes are removed and measured.

With the ICP-MS, quantitative proofs in the range of nanograms per litre (ng/l) or better can be achieved for most elements of the periodic table. The list of orders of magnitude can be extended to up to nine further values in an extremely high linear range. This means that measurements and verifications are possible from grams/litre to picograms/litre. As already mentioned, not only the elements are measured, their isotopes are also recorded – this is how extremely precise isotope analysis can be carried out within the framework of ICP-MS. High-resolution ICP mass spectrometers are often used for this purpose.

Within the scope of coupling with some analytical separation methods such as high-performance liquid chromatography, gas chromatography, capillary electrophoresis, gel electrophoresis, ion exchange chromatography and field-flow fractionation, the ICP-MS analysis passages can also be used for speciation analysis. In addition, the analysis of solid samples can be made possible by direct coupling with a special furnace for electrothermal evaporation or with a laser ablation device.

Application areas of the ICP-MS

This very principle of coupling with a special furnace or a laser ablation device also makes it possible to perform virtually non-destructive analytical processes on, for example, historical samples. However, qualitative, quantitative and semi-quantitative elemental analysis are the main areas of application for ICP-MS. This analysis principle is also used for age determination of geological samples, for food analysis and authentication and for protein analysis. Other areas include the absolute and relative quantification of proteins and other bio-molecules, toxicological issues, forensic and clinical analysis and quality assurance.

Cooperating suppliers

Our [FP]-LIMS is compatible with a large number of well-known manufacturers in the industry. Due to years of experience and the high demands on ourselves, we have extended the compatibility of the software in the past years more and more. Among others, the devices of the following manufacturers are compatible with our [FP]-LIMS: Hitachi, Bruker, Spectro Ametek, ThermoFisher Scientific, Agilent Technologies, analytikjena, Horiba Scientific, Malvern Panalytical, Microtrac, PerkinElmer and Zwick Roell.

Especially with regard to the ICP-MS we support instruments of the brands Spectro / Ametek, Bruker, Thermo Fisher, Perkin Elmer and Analytik Jena.

The Fink & Partner [FP]-LIMS in your laboratory

Experience the [FP]-LIMS now as a reliable and competent partner for the storage and processing of all your measurement data. You benefit not only from a much lower workload, but also from the provision of all important certificates and data analyses in real time.

You have a device for mass spectrometry and want to combine the measured data in a LIMS software solution?